TNF and hypertensive disorder: They found that IL-6, IL-8, and TNF-α endothelial cell expression was upregulated and suggested that hypertension activates endothelial cells to increase the expression of adhesion molecules and cytokines and induces neutrophil and monocyte adhesion and migration, resulting in endothelial cell injury and increased permeability of endothelial cells, which results in hypertensive arterial disease [18].