Lastly, catecholaminergic polymorphic ventricular tachycardia (CPVT), a stress-induced ventricular rhythm disease caused by mutations in the cardiac ryanodine receptor isoform 2 (RyR2) gene, has also been shown in CMs derived from iPSCs isolated from patients with CPVT (CPVT1-CMs) [131, 132]. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.