Intriguingly, a model system developed by the Chen group [124, 140] showed that, in order to fully recapitulate meaningful ARVC disease readouts, patient specific iPSC-CMs needed to be metabolically matured and stimulated with activators of the PPAR-gamma pathway which is hyperactivated in ARVC right ventricles [125]. This evidence concerns the gene PPARG and Arrhythmogenic right ventricular dysplasia.