PKP2 and heart failure: Arrhythmogenic right ventricular cardiomyopathy (ARVC), also known as arrhythmogenic cardiomyopathy, is a cardiac disease of genetic origin which occurs due to mutations in cardiac desmosomal proteins, for example, plakophilin-2 (PKP2), which leads to ventricular tachyarrhythmias progressing to heart failure.