However, 2 trials (Prospective Randomised Study of Ventricular Function and Efficacy of Digoxin, PROVED [7], and Randomised Assessment of Digoxin and Inhibitors of Angiotensin-Converting Enzyme, RADIANCE [8]) have shown positive differences (compared to ischaemic heart disease patients) in left ventricle ejection fractions in patients with nonischaemic dilated cardiomyopathy (DCM) receiving digoxin alone or in combination with inhibitors of angiotensin-converting enzyme. The gene discussed is ACE; the disease is familial dilated cardiomyopathy.