Pathway analysis on these genes showed association with well-known cancer biomarkers (Fig. 6c), such as a suppressor of retinoblastoma RB-P107 (P = 9.88 × 10−9), but also P53 (P = 5.98 × 10−7), LEF1 (P = 5.41 × 10−6), MEK (P = 2.63 × 10−6), E2F1 (P = 3.54 × 10−5), KRAS (P = 5.8 × 10−4) (detailed information can be found in Supplementary Table S6 and Methods section). The gene discussed is LEF1; the disease is retinoblastoma.