ERBB2 and breast cancer: Subtype analysis of the 563 breast cancer samples using MEREDITH resulted in five distinct clusters (Fig. 5a) that were significantly associated with the known breast cancer subtypes: i) cluster 1 for the Luminal A subtype (P = 5.1 × 10−6); cluster 2 also for Luminal A (P = 6.2 × 10−4); iii) cluster 3 for the Basal subtype (P = 3.9 × 10−14); iv) cluster 4 for the Basal and HER2-type (P = 1.5 × 10−3 and P = 0.035 respectively); and v) cluster 5 for the Luminal B subtype (P = 1.6 × 10−6).