In general, patients with AML are separated into three groups, i.e., patients with abnormal karyotype (e.g., translocations, t(8;21), t(15;17) or inversions inv(16)), normal karyotype (usually with point mutations in the genes FLT3ITD, NPM1, IDH1), and complex karyotype (with multiple (cyto)genetic abnormalities, e.g., 3q, 7q, and trisomy 8). Here, IDH1 is linked to acute myeloid leukemia.