CASP8 and B-cell chronic lymphocytic leukemia: Moreover, Lyn-mediated phosphorylation of Y380 was found to promote resistance to apoptosis in chronic lymphocytic leukaemia due to the formation of an inactive procaspase-8 homodimer.25 In addition, tumours displaying intrinsic Y380 phosphorylation such as chronic lymphocytic leukaemia and colon cancer could potentially be treated by inhibiting Src activity via medicinal intervention, thus removing the caspase-8 Y380-mediated block on cell death and potentially sensitizing them to apoptosis-inducing drugs.