CASP8 and colonic neoplasm: Indeed, a concomitant increase in both Src and caspase-8 phosphorylation and associated resistance to Fas-induced apoptosis is observed in colon cancer.14 Furthermore, Src inhibition can sensitize colon cancer cells to apoptosis22, 23 and since we observed that Y380 phosphorylation also has a role in cell migration, Src inhibition may further help prevent tumour metastasis.