To investigate this, we generated caspase-8-deficient SH-SY5Y neuroblastoma cells overexpressing equivalent amounts of wild-type procaspase-8b (Casp-8b-WT) and mutant variants, namely Casp-8b-Y380E and -Y380F; which mimic constitutive phosphorylation at Tyr380 by replicating its charge characteristics and prevent phosphorylation at this site, respectively (Figures 1a and b). The gene discussed is CASP8; the disease is neuroblastoma.