To further investigate the potential mechanisms of how FOXM1 and CENPF mediated COUP-TFII function to promote tumour metastasis, we specifically constructed a metastasis gene regulatory network in PCa using neoplasm metastasis-related genes classified by MetaCore and crossing them with the gene list changed in the metastatic PCa (Supplementary Fig. 12). This evidence concerns the gene FOXM1 and posterior cortical atrophy.