In addition, Gene Set Enrichment Analysis (GSEA) of the molecular signatures' database indicated that downstream target genes of miR-101, miR-27a as well as COUP-TFII mRNA and its signatures were significantly depleted (miR-101 and miR-27a) or enriched (COUP-TFII) in the metastatic PCa patient (Fig. 1d). This evidence concerns the gene NR2F2 and posterior cortical atrophy.