The hypoxia-induced extracellular matrix remodelling factor P4ha2 (ref. 38), marker of tumour vasculature Igfbp7 (ref. 39), as well as Gpc1, a co-receptor for heparin-binding growth factors such as FGFs and modulator of angiogenesis and metastasis of human and mouse tumours40 were also downregulated in the absence of Blimp1. The gene discussed is IGFBP7; the disease is neoplasm.