To measure effects of atherosclerosis development on exercise capacity of female ApoE/LDLR−/− mice we measured whole body maximal oxygen consumption (V’O2max), maximal velocity (vmax) achieved and maximal distance (DISTmax) covered during incremental test for V’O2max measurement by young 3-month old female ApoE/LDLR−/− mice with early atherosclerosis and older 6–8-month old female ApoE/LDLR−/− mice with advanced atherosclerosis26 as compared with age-matched control C57BL6/J mice. This evidence concerns the gene LDLR and atherosclerosis.