APOE and atherosclerosis: Moreover, both younger (3-month old) female ApoE/LDLR−/− mice and older (6–8-month old) female ApoE/LDLR−/− mice with early and advanced peripheral (as reported earlier26) and early and advanced coronary (as shown here) atherosclerosis achieved higher velocities and covered longer distances than age-matched C57BL6/J mice (Fig. 1D,E).