Interestingly, vmax and DISTmax declined with age only in female ApoE/LDLR−/− mice but not in C57BL6/J mice (35.84 m·min−1 for younger vs 30.82 ± 1.12 m·min−1 for older female ApoE/LDLR−/− mice, n = 11−19, P = 0.0118 and 509.2 ± 34.97 m for younger vs 359.4 ± 22.9 m for older female ApoE/LDLR−/− mice, n = 11, P = 0.0052, respectively) probably due to atherosclerosis progression (Fig. 1D,E). The gene discussed is APOE; the disease is atherosclerosis.