In this study we characterized whole body maximal oxygen uptake (V’O2max), exercise capacity and NO- and PGI2-dependent coronary endothelial function of female ApoE/LDLR−/− mice with respect to age-related peripheral atherosclerosis progression described elsewhere26 and age-related coronary atherosclerosis progression shown here. This evidence concerns the gene LDLR and coronary atherosclerosis.