In this study we found that, in spite of age-dependent peripheral atherosclerosis progression described earlier26 and coronary atherosclerosis progression described in this paper, changes in coronary flow induced by Bk (0.03, 0.1, 0.3, 1.0 nmol) in isolated hearts from female ApoE/LDLR−/− mice were not impaired compared with age-matched C57BL6/J mice (Fig. 2A–C). The gene discussed is APOE; the disease is coronary atherosclerosis.