Moreover, cardiac performance at rest as well as its inotropic and lusitropic reserve were well preserved in 6–8-month old female ApoE/LDLR−/− mice (Fig. 6) with advanced coronary atherosclerosis (Fig. 5G–I) compared with age-matched C57BL6/J mice as evidenced by similar FAC, and slice-derived ESV and EDV in basal conditions as well as in response to dobutamine. Here, APOE is linked to coronary atherosclerosis.