NOTCH1 and head and neck squamous cell carcinoma: To determine the role of NOTCH1 pathway in chemotherapy, we utilized cherish paired specimen (postchemotherapeutic specimen and prechemotherapeutic biopsy in the same patient) with induction-combined TPF chemotherapy of human HNSCC using docetaxel (DTX), cisplatin (CDDP) and 5-fluorouracil (5-FU) for validation24.