As TGF-β1 is a profibrotic growth factor that stimulates α-SMA expression and myofibroblast differentiation, we investigated the paradox that TGF-β1 hypersecretion in MSC resulted in an increased level of IP-10 in UIP-HLF and concurrently reduced α-SMA expression. The gene discussed is CXCL10; the disease is idiopathic pulmonary fibrosis.