IL6 and incontinentia pigmenti: However, we show a significant up-regulation of the TGF-β1 level accompanied by a reduced Tregs and down-regulation of the ratio of TGF-β1 to IL-6 in the CTD-IP patients, reflecting that the increase of endogenous TGF-β1 released from immunocytes in response to the inflammatory microenvironment could not induce Tregs differentiation owing to IL-6 hypersecretion that causes an imbalance between IL-6 and TGF-β1 in local and systemic modulation of the immune response, thereby disturbing TGF-β1 signaling.