Meanwhile, elevation of CD3+ CD8+ cells (29.96 ± 7.62 % in CTD-IP vs. 26.40 ± 4.78 % in control, P = 0.048) and reduction of CD3+ CD4+ cells (32.23 ± 6.95 % in CTD-IP vs. 35.71 ± 4.69 % in control, P = 0.046) were also detected (Fig. 2a–c). The gene discussed is CD4; the disease is incontinentia pigmenti.