ZNF521 and lymphoid neoplasm: We examined Pax5 because Pax5 expression levels are increased in lymphoid tumors from mice with retroviral insertions at the Evi3 site [8], supporting the hypothesis that Pax5 is downstream of Zfp521. To control for changes in viable cell number caused by general proliferative actions of the rescue candidates, we calculated the ratio of increase in viable cell number on day 7 for cells in each knockdown condition receiving the rescue plasmid (day 7 + ) as compared to cells without the addition of rescue plasmid (day 7).