The WHO classification from 2010 divides small intestinal neuroendocrine neoplasms in three grades; G1-NETs (Ki67 < 3 %), G2-NETs (Ki67 3–20 %) and NEC (neuroendocrine carinomas, Ki67 > 20 %) [3]. The gene discussed is MKI67; the disease is small intestine neuroendocrine neoplasm.