For rs3178250 (BMP2) (ORTC/CC = 1.18, 95 % CI 0.99–1.40) we observed that the heterozygote genotype (relative to homozygous normal) was associated with ~25 % elevated colon cancer risk, while the rare homozygous variant genotype was (non-significantly) associated with reduced risk. This evidence concerns the gene BMP2 and colonic neoplasm.