Eleven SNPs were associated (P < 0.05) with colon cancer risk, and two of these variants remained significant after correction for multiple comparisons (PHolm < 0.05): rs1967327 (PRKRA) (ORdom = 0.78, 95 % CI 0.66–0.92) and rs4548444 (MAPKAP2) (ORrec = 1.67, 95 % CI 1.12–2.48). This evidence concerns the gene PRKRA and colonic neoplasm.