In a reciprocal experiment (Figure S1I), Dox-induced CD44 KD in vivo suppressed tumor growth in nude mice (Figure 1E) and in non-obese diabetic/severe combined immuno-deficient mice with IL2R knock-out (NOD/LtSz-scid/IL2Rγnull) (referred to here as NSG mice) purchased from Jackson Laboratory (Bar Harbor, ME) (NSG) mice [28, 29]. This evidence concerns the gene IL2RA and neoplasm.