While these cells were able to efficiently migrate towards chemokine (even more than the CLL B cells), 17-DMAG was not able to significantly inhibit the migration of these cells towards SDF-1 (p = 0.556) or CXCL13 (p = 0.389) (Figure 4B), which is consistent with the real time data showing less induction of SOCS3 in normal B cells. Here, CXCL12 is linked to B-cell chronic lymphocytic leukemia.