It is noted that knocking down the expression of DSG2 suppressed the proliferation (Figure 5E mock+Scr vs PNN+Scr p<0.001, PNN+Scr vs PNN+Si-DSG2 p<0.001 and Figure 5F mock+Scr vs PNN+Scr p=0.004, PNN+Scr vs PNN+Si-DSG2 p=0.009), migration (Figure 5G) of CRC cells in spite of PNN overexpression. The gene discussed is DSG2; the disease is colorectal carcinoma.