SMPD1 and neoplasm: To this end we used two cell clones B16-W6_scr and B16-W6_pSIL10 already characterised for tumourigenic potential and A-SMase activity: B16-W6_pSIL10 shows significantly lower expression/activity of A-SMase than B16-W6_scr and significantly higher tumour-inducing potential [38].