It showed that miR-1207-5p can downregulate STAT3 and AKT signalings, as well as their downstream targets, including some important inflammatory mediators such as IL-10, CCL5 and CXCL10. We also showed that miR-1207-5p can regulate a few of important EMT-related molecules such as Snail, Smad 2, Smad3, Smad7, Vimentin, and ZEB1, which indicated the inhibition role of miR-1207-5p in tumor invasion and metastasis. Here, SMAD3 is linked to neoplasm.