Today's therapeutic strategies to overcome FRDA symptoms include (i) increasing frataxin level (e.g. HDAC inhibitors, erythropoietin) (Rai et al., 2008; Sturm et al., 2005b), (ii) reducing iron mediated toxicity through iron chelators (e.g. deferiprone) (Boddaert et al., 2007; Kakhlon et al., 2008) or (iii) improving the cellular antioxidant defense (e.g. idebenone, PPARγ agonists, Nrf2 inducers) (Marmolino et al., 2010; Hausse et al., 2002; Mariotti et al., 2003; Shan et al., 2013). This evidence concerns the gene FXN and Friedreich ataxia.