IRS1 and Cognitive impairment: Interestingly, with regards to the two other proteins involved in the putative metaflammasome, IRS1 and PKR, we observed a high expression related with worse cognition, but not with the presence of dementia (frank dementia usually reflecting the latest stage of neurodegeneration), perhaps implying that these components might be involved in the earlier stages of AD or in mild cognitive impairment.