The role of lysosomes in tumor progression is complex and consists of three notable functions: 1) Following fusion with lipid inclusion bodies, lysosomes play a role in the hydrolysis of stored and internalized neutral lipids through lysosomal acid lipase (LAL) activity [2, 3]; 2) Lysosome trafficking has been linked to nutrient-sensing signaling cascades involving mammalian target of rapamycin (mTOR) activity and autophagy [4]; 3) Lysosomes supply proteases for ECM degradation that can lead to invasion and metastasis [1]. Here, LIPA is linked to neoplasm.