RILP and neoplasm: For example, the lysosome-localized GTPase Rab7 is well-known for its role in recruiting dyneins to lysosomes through its effector Rab-interacting lysosomal protein (RILP) [14], and we have recently established a role for Rab7 as a potential tumor suppressor via its ability to cluster lysosomes near the MTOC [8].