To test wheter the effects of Omomyc on SCLC cells were a consequence of the specific inhibition of the MYC pathway, MYC expression in Lu135omo cells was suppressed using a siRNA for MYC. The amounts of p21 and p27, as well as the percentage of cleaved PARP1, were increased in Lu135omo cells by MYC knockdown (Figure 5A). The gene discussed is CDKN1A; the disease is small cell lung carcinoma.