NOTCH1 and sarcoma: The genes repressed by EC-8042 included important pluripotency factors like SOX2 and C-MYC, markers of CSCs in different types of tumors, including sarcomas, like ENG/CD105, ABCG2, KIT/CD117, CD44 and ALCAM/CD166, genes involved in proliferation and asymmetric division such as LIN28B, ERBB2, SIRT1 and KITLG, genes involved in metastasis like TWIST1, ZEB1 and PLAT and genes involved in relevant stemness signaling pathways like NOTCH signaling (NOTCH1, MALML1 and JAG1), NFκB signaling (NFκB1 and IκBKB) or Hippo signaling (TAZ, WWC1, LATS1 and YAP1) (Figure 4C).