PTC-209 strongly inhibits growth of colon cancer cells and CSC phenotype, and BMI1 downregulation using siRNA approach or its inhibition by histone deacetylase inhibitors (HDACi) and PLK1 inhibitors is known to induce premature senescence in normal and breast cancer cells [27, 28, 36]. This evidence concerns the gene PLK1 and malignant colon neoplasm.