As shown in Figure 4B and 4C, InuA upregulated the expression of p21 and Bax, induced the cleavage of PARP, and reduced the expression of Cdk2, Cdk4, Cdk6, Cyclin D1, Cyclin E, c-Myc, and Bcl2 in both breast cancer cell lines. This evidence concerns the gene CCNE1 and breast cancer.