TP53 and breast carcinoma: Among this, breast cancer MCF7 (p53 wild-type), MCF7 p53 knockdown (KD), MDA-MB-231 (p53 mutant), and MDA-MB-468 (p53 mutant) cells exhibited strong sensitivity to InuA treatment, with the IC50 values of 2.4, 3.7, 4.1, and 0.9 μM, respectively (Figure 1).