In this study, we found (i) that NLRP12 inhibits IL-1β release during DSS-induced mice colitis in NLRP3 inflammasome-independent manner; (ii) that Blimp-1 down-regulates NLRP12 expression during DSS stimulation; and (iii) that TLR4 participates in Blimp-1-mediated NLRP12 down-regulation during the development of mice colitis. Here, PRDM1 is linked to colitis.