Measurement and analysis of serum PSA (Figures 2B i), tumor volume (Figures 2B ii), and bioluminescent imaging (Figures 2B iii) showed that bioluminescent imaging was proportional to serum PSA level (R2 coefficient = 0.896) (Figures 2C i) and tumor volume (R2 coefficient = 0.899) (Figures 2C ii), R2 coefficient: 0.799 was proportional between serum PSA (ng/ml) and tumor volume (mm3) (Figures 2C iii). The gene discussed is KLK3; the disease is neoplasm.