CCN1 and neoplasm: Consistent with the data from clinicopathological analysis with IHC staining, knockdown of CYR61 in gastric cancer AGS cells severely impaired cell migration and invasion, the two key cellular processes in metastasis, but had a minor inhibitory effect on cell proliferation (Figures 2 and 3), suggesting that CYR61 is a driver for metastasis, but not for tumor growth.