Furthermore, IL-2, IL-17, IL-23, TNF-β, GM-CSF, MCP-1, RANTES, eotaxin, IL-4, IL-5, IL-10 and G-CSF are also closely related with cognitive decline with ageing, synaptic or neuronal loss [85–91], osteoarthritis [92, 93] cancer [94], lung senescence [95]. This evidence concerns the gene CSF2 and osteoarthritis.