Since membranous-cytoplasmic accumulation of Ccnd1 was seen at the periphery of nests in collective and pushing invasion patterns of endometrial carcinoma samples, but also in correlation with Gleason grade, and pT3 in prostatic cancer, we selected endometrial and prostatic cancer as models to further validate the role of Ccnd1 in invasion. The gene discussed is CCND1; the disease is endometrial carcinoma.