PFKFB3 and neoplasm: Despite comparable tumor volume size (data not shown), DTC tumors showed increased levels of hypoxia-regulated genes such as the cytokine VEGF [20], Adm (adrenomedullin) [21], Bnip3 (BCL2/Adenovirus E1B 19kD-Interacting Protein 3) [22], Pfkfb3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3) [23], Itga9 (Integrin alpha-9) [24], and NRG1 (neuregulin 1) [25] (Figure 2B).