Since the anti-apoptotic factor Bcl2 is well known to counteract cisplatin-induced apoptosis in cancer cells [24], its expression can be regulated by IRES-dependent translation [34], and because we observed a correlation between La and Bcl2 levels in HNSCC cells (Figure 1), we tested whether depletion of the La protein affects Bcl2 protein level. This evidence concerns the gene SSB and cancer.