By taking the 8 most frequently mutated genes in CRC (derived from The Cancer Genome Atlas Network [24]), we performed a computational analysis and found that, of these, KRAS, TP53, and FBXW7 displayed the largest differences in mutation frequency between URI1-sensitive and URI1-insensitive cell lines (Supplementary Figure S1E). The gene discussed is URI1; the disease is colorectal carcinoma.