Resistance to sorafenib-induced downregulation of eIF4E and p70S6K/RP-S6 signaling in our sorafenib-resistant cells led to the resistance to sorafenib-mediated downregulation of AIB1, which contributes to the acquired resistance of HCC cells to sorafeinb-induced cell death. This evidence concerns the gene EIF4E and hepatocellular carcinoma.