BPI and infection: It is a major constituent of the outer membrane of Gram-negative bacteria and consists of polysaccharides and a lipid structure named lipid A. Many innate immune-related genes regulated by LPS have been investigated [2]; among them, bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide binding protein (LBP) play crucial roles in the response to the infection of Gram-negative bacteria [5].