An additional multiple-SNP analysis for TLR9 -1237T/C, -1486T/C, and 2848C/T showed that the TCT haplotype was observed at a lower frequency in both infant groups (24.3% and 14.7% for HCMV-infected and uninfected cases, respectively) and it was associated with 2.5-fold increased the risk of HCMV infection (OR 2.47, 95% CI 1.14–5.33, P = 0.023). The gene discussed is TLR9; the disease is cytomegalovirus infection.