Many reports showed that CETP, LIPC and LIPG were associated with HDL and LDL [60–62] and that MTHRR had known main effects for LDL [63] and blood pressure [64], NR1I3 for lipid metabolism [65], PLTP for LDL [66],[67], FOXO1 for LDL [68] and hypertension [69], SMAD9 for hypertension [70], and CSMD1 for SBP [51]. This evidence concerns the gene SMAD9 and hypertensive disorder.