Finally, the bipartite Rac1 GEF composed of Dock180 and ELMO1 is overexpressed in malignant gliomas, where it contributes to invasion,63 whereas LARG (leukemia-associated Rho GEF) is found fused with the MLL locus in acute myeloid leukemia (AML)64 leading to aberrant expression. The gene discussed is KMT2A; the disease is acute myeloid leukemia.