Finally a less well-studied GTPase, Rnd3/RhoE is downregulated in HCC (hepatocellular carcinoma) and its downregulation is correlated with poor prognosis and tumor progression,41,42 while it is upregulated in gastric cancer cells under hypoxic conditions promoting EMT,43 again highlighting the signaling complexity of these GTPases and their downstream targets. This evidence concerns the gene RND3 and neoplasm.