It should be noted that also pairings of COX-2 inhibitors and non-responding cell-lines have been described, namely celecoxib and human prostate cancer cell lines PC-3, DU145, and LNCaP [74], NS-398 and prostate carcinoma PC-3 cells [75], and nimesulide and head-and-neck carcinoma cells SSC9 and SCC25 [76]. This evidence concerns the gene PTGS2 and prostate carcinoma.