Moreover, our insights on the regulation of eIF4E phosphorylation raise questions related to (i) the role of p-eIF4E on VPg-mediated viral translation; (ii) the global extend of cellular mRNA translational reprogramming and (iii) the role of the mTOR pathway in controlling eIF4E availability during calicivirus infection. The gene discussed is MTOR; the disease is Caliciviridae infectious disease.