Polymorphisms and mutations in several genes, such as transforming growth factor β (TGF-β), bone morphogenetic protein (BMP), growth differentiation factor 5 (GDF5), secreted frizzled-related protein 3 (FRZB), and matrilin-3 (MATN3) predisposes individuals to early-onset osteoarthritis [13,14,15,16,17,18,19,20]. The gene discussed is GDF5; the disease is osteoarthritis.