The SIRT1 tagging SNPs (rs7895833 A/G, rs1467568 A/G, and rs497849 G/A) were also assessed in the Rotterdam Study cohort (4573 individuals, among them 413 were diagnosed with T2DM and 378 developed T2DM during the follow-up) for their association with type 2 diabetes. This evidence concerns the gene SIRT1 and type 2 diabetes mellitus.