SIRT1 and type 2 diabetes mellitus: Other SIRT1 variants, G allele of rs7896005 (A/G) SNP (tagged to promoter rs3758391 SNP that alters the putative p53 binding site) and T allele of rs10509291 (A/T), were found to be associated with a risk of T2DM and a decrease in acute insulin secretion in 3501 Pima Indians; however, this association was not confirmed in another group of 3003 Native Americans.