An association between the rs12413112 (G/A), rs33957861 (C/T), rs11599176 (A/G) and rs35689145 (G/A) SIRT1 variants, all within high LD and obesity, was confirmed in 896 unrelated French cases and 532 normal-weight controls, and replicated in 154 Swedish families (732 subjects) [77]. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.