LCAT and cardiovascular disorder: Furthermore, although large HDL particles are more strongly predictive of cardiovascular disease prevention than HDL cholesterol levels, our study did not measure levels of HDL functionality, CETP activity, or lecithin-cholesterol acyltransferase (LCAT) activity, which may have added important insights (Kontush et al., 2013[18]; Miller, 2015[25]; Scharnagl et al., 2014[36]; Sprandel et al. 2015[41]).