HP and obesity due to melanocortin 4 receptor deficiency: Since it is reported that haptoglobin implicates in acute phase response to inflammation in which the high levels of haptoglobin were found in several diseases that involve in cardiovascular disease and inflammation such as overweight/obesity, artherothombotic ischemic stroke, and myocardial infarction (Chiellini et al., 2004[9]; De Pergola et al., 2007[15]).