Studies performed in live cultured precision-cut lung slices obtained from a patient with IPF confirmed prominent Akt phosphorylation in lung tissue and this signal was reduced in a concentration-dependent manner following incubation with a closely related analogue of GSK2126458, Compound 1 (figure 2) (see online supplementary figure S2 for compound structures and online supplementary table S1 for compound affinity data). Here, AKT1 is linked to idiopathic pulmonary fibrosis.