TGFB1 and idiopathic pulmonary fibrosis: Progressive, excessive and disorganised deposition of collagen and other extracellular matrix (ECM) proteins underlies the gross remodelling leading to loss of lung function in IPF, with TGFβ1 implicated as a critical mediator of this process.5 Recent reports have further suggested the involvement of the PI3K signalling axis in SMAD-independent TGFβ1 signalling.15, 28 We therefore also explored the potential of GSK2126458 to interfere with TGFβ1-induced fibroblast collagen production.