Recently, it has been reported that in 95 to 100% of bacteremia patients the IgG response is significantly induced targeting several antigens including the immune modulators staphylococcal superantigen-like protein 3 (SSL3), SSL10, the immune evasion protein SCIN, the toxins γ-hemolysin (HlgB) and leukocidin F (LukF), a putative ABC transporter SA0688, the membrane-associated foldase PrsA and the surface bound and extracellular enzyme IsaA48. The gene discussed is SCIN; the disease is bacterial infectious disease with sepsis.