This is consistent with the infertility or sub-fertility of Gapdhs−/−, Pgk2−/− and Eno4Gt/Gt knockout male mice, which lack testis-specific forms of the glycolytic enzymes glyceraldeyhde-3-phosphate dehydrogenase, phosphoglycerate kinase and enolase, respectively (Danshina et al., 2010; Miki et al., 2004; Nakamura et al., 2013). The gene discussed is PGK2; the disease is Infertility.