GPI/AMF is secreted by tumour cells, protects cells from endoplasmic reticulum stress (ER stress) and apoptosis, and promotes cell motility, epithelial to mesenchyme transition and invasion and metastasis of tumour cells (Fu et al., 2011; Funasaka et al., 2009; Kim and Dang, 2005). This evidence concerns the gene GPI and neoplasm.