However, there are encouraging results, in the form of anecdotal reports, on the response of chordoma to epidermal growth factor receptor (EGFR) 8, 9, 10, 11, 12, 13 and vascular endothelial growth factor (VEGF) inhibitors 5, 12, 13, 14, although data from prospective randomized clinical trials are lacking 5, 14. This evidence concerns the gene EGFR and chordoma.