Furthermore, early (postnatal) high‐carbohydrate diets reduced Glut4 transcription in the skeletal muscle of the adult offspring (100 days postgestation) via epigenetic modifications including an increased methylation of the Glut4 promoter and acetylation of H2 variant (H2A.Z) and H4, importantly highlighting a novel epigenetic mechanism contributing to early‐life nutrient stress that is associated with later‐life adult insulin resistance and obesity (Raychaudhuri et al., 2014). Here, SLC2A4 is linked to obesity due to melanocortin 4 receptor deficiency.