SIRT3 and type 2 diabetes mellitus: Indeed, maternal low protein (8%) and postnatal high diets (45%) in the rats have been shown to increase the risk of type II diabetes by decreasing skeletal muscle oxidative respiration, via increased sirtuin 3 (Sirt3), and potentially by decreasing the activity of succinate dehydrogenase (SDH) (Claycombe et al., 2015).