To establish whether IRF4 is the downstream gene which mediates the apoptotic program triggered following JMJD3 depletion in DLBCL cells, we depleted IRF4 in both ABC (OCI-ly3 and SU-DHL-2) and GCB (OCI-ly19 and VAL) DLBCL cells. Here, KDM6B is linked to diffuse large B-cell lymphoma.