From all the miRNA candidates, we specifically found that KLF4 overexpression increased the levels of miR-153, miR-506 and miR-200b in both HCC cell lines, while KLF4 depletion decreased the levels of miR-153, miR-506 and miR-200b in both HCC cell lines (Figure 1C). Here, KLF4 is linked to hepatocellular carcinoma.